Robson Coutinho-Silva Selected Research

(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)- 2,2- dimethylpropyl)- 2- (3,4- dimethoxyphenyl)acetamide)

4/2022	The P2X7 Receptor Promotes Colorectal Inflammation and Tumorigenesis by Modulating Gut Microbiota and the Inflammasome.
1/2014	Prophylactic systemic P2X7 receptor blockade prevents experimental colitis.

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Robson Coutinho-Silva Research Topics

Disease

29	Inflammation (Inflammations) 07/2022 - 01/2008
28	Infections 01/2022 - 09/2003
5	Neoplasms (Cancer) 04/2022 - 01/2017
5	Sepsis (Septicemia) 01/2021 - 01/2015
4	Silicosis 01/2020 - 01/2014
4	Colitis 11/2017 - 01/2014
3	Hyperhomocysteinemia 07/2022 - 12/2015
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2022 - 03/2014
3	Communicable Diseases (Infectious Diseases) 01/2022 - 01/2018
3	Fibrosis (Cirrhosis) 01/2020 - 12/2009
3	Cutaneous Leishmaniasis 01/2018 - 09/2011
3	Schistosomiasis (Bilharziasis) 01/2016 - 03/2013
2	Neuroinflammatory Diseases 07/2022 - 01/2016
2	Cognitive Dysfunction 07/2022 - 01/2021
2	Periodontal Diseases (Periodontal Disease) 12/2021 - 01/2019
2	Body Weight (Weight, Body) 07/2021 - 01/2020
2	Leishmaniasis 01/2021 - 01/2016
2	Peritonitis 01/2021 - 01/2020
2	Pneumonia (Pneumonitis) 01/2020 - 01/2014
2	Lung Diseases (Lung Disease) 01/2020 - 09/2015
2	Periodontitis 01/2020 - 01/2019
2	Toxoplasmosis 01/2019 - 01/2017
2	Necrosis 01/2015 - 12/2012
2	Lung Injury 01/2015 - 12/2011
2	Tuberculosis (Tuberculoses) 07/2014 - 08/2013
1	Ulcer 04/2022
1	Colitis-Associated Neoplasms 04/2022
1	Carcinogenesis 04/2022
1	Wounds and Injuries (Trauma) 01/2021
1	Edema (Dropsy) 01/2020
1	Ureteral Obstruction 01/2020
1	Parasitic Diseases (Parasitic Disease) 01/2019
1	Cerebral Toxoplasmosis 01/2019
1	Asthma (Bronchial Asthma) 01/2019
1	Brain Injuries (Brain Injury) 10/2017
1	Delirium 10/2017

Drug/Important Bio-Agent (IBA)

34	Purinergic P2X7 ReceptorsIBA 04/2022 - 12/2011
27	Adenosine Triphosphate (ATP)IBA 01/2022 - 12/2003
16	CytokinesIBA 12/2021 - 12/2009
10	Purinergic Receptors (Receptors, Purine)IBA 01/2019 - 05/2005
9	InflammasomesIBA 04/2022 - 09/2015
8	NucleotidesIBA 01/2021 - 05/2005
4	Proteins (Proteins, Gene)FDA Link 07/2021 - 02/2016
4	CollagenIBA 01/2021 - 01/2014
4	Adenosine (Adenocard)FDA LinkGeneric 01/2020 - 01/2017
3	HomocysteineIBA 07/2022 - 12/2015
3	Messenger RNA (mRNA)IBA 01/2020 - 05/2005
3	Silicon Dioxide (Silica)FDA LinkGeneric 01/2020 - 01/2014
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 01/2018
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 01/2015
3	Uridine Triphosphate (UTP)IBA 01/2018 - 09/2011
2	(N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)- 2,2- dimethylpropyl)- 2- (3,4- dimethoxyphenyl)acetamide)IBA 04/2022 - 01/2014
2	Adenosine Diphosphate (ADP)IBA 01/2021 - 01/2016
2	Purinergic P2Y1 ReceptorsIBA 01/2021 - 01/2016
2	ChemokinesIBA 12/2020 - 01/2016
2	coomassie Brilliant BlueIBA 01/2020 - 01/2014
2	Virulence Factors (Pathogenicity Factors)IBA 01/2019 - 06/2009
2	Sulfates (Sulfates, Inorganic)IBA 12/2018 - 11/2017
2	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 12/2018 - 11/2017
2	OxazoloneIBA 11/2017 - 01/2017
2	AcidsIBA 01/2017 - 01/2014
2	EnzymesIBA 01/2017 - 07/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 01/2008
2	LipopolysaccharidesIBA 12/2011 - 01/2008
1	Ibuprofen (Motrin)FDA LinkGeneric 07/2022
1	Synapsins (Synapsin I)IBA 07/2022
1	Rivastigmine (Exelon)FDA LinkGeneric 07/2022
1	AcetylcholinesteraseIBA 07/2021
1	SuspensionsIBA 07/2021
1	Caspase 3 (Caspase-3)IBA 07/2021
1	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 07/2021
1	Interleukin-10 (Interleukin 10)IBA 07/2021
1	NeurotoxinsIBA 01/2021
1	Meglumine AntimoniateIBA 01/2021
1	Clemastine (Clemastine Fumarate)FDA LinkGeneric 01/2021
1	Dietary Fiber FDA Link 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	Minocycline (Cyclops)FDA LinkGeneric 01/2021
1	pexidartinibIBA 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021
1	Macrophage Colony-Stimulating FactorIBA 01/2021
1	Uric Acid (Urate)IBA 01/2020
1	CD39 antigenIBA 01/2020
1	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2020
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2020
1	NitritesIBA 01/2020
1	NucleotidasesIBA 01/2020
1	Purinergic P2Y Receptor AntagonistsIBA 01/2020
1	5'-Nucleotidase (5' Nucleotidase)IBA 01/2020
1	GTP-Binding Proteins (G-Protein)IBA 01/2020
1	Clopidogrel (Plavix)FDA Link 01/2020
1	CreatineIBA 01/2019
1	Leukotriene B4IBA 01/2019
1	Interleukin-5 (Interleukin 5)IBA 01/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2018
1	Ligand-Gated Ion ChannelsIBA 01/2018
1	HMGB1 Protein (HMG1)IBA 01/2018
1	LeukotrienesIBA 01/2018

Therapy/Procedure

5	Ligation 12/2020 - 09/2003
3	Punctures 12/2020 - 01/2015